To investigate the glucokinase activity of flavonoids in alloxan-induced diabetes rats. The effects of orally administered flavonoids (Quercetin Chrysin & Hesperdin) on serum glucose and lipid profiles were examined in diabetic rats. While the activities of glucokinase, in the serum were assessed. The flavonoids were administered over a period of 21 days. The quercetin chrysin & hesperdin and Pioglitazone were significantly (P<0.01) reduced serum glucose levels, lipid profiles but increased activities of glycolytic enzyme, glucokinase. The present investigation suggests that quercetin chrysin & hesperdin and pioglitazone exhibit glucokinase activation and reduced blood glucose levels in diabetic rats.
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